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ORYNOCOAT ESC details

The perfect blend of art and science in coating materials
ORYNOCOAT® ECS is a non-aqueous enteric coating system designed to protect acid-sensitive drugs from gastric fluids. It ensures the active ingredient is released only when it reaches the higher pH environment of the small intestine, supporting delayed and targeted drug delivery.
  • Acid Resistance Effectively shields APIs from degradation in the stomach’s acidic conditions.
  • Intestinal Release Dissolves only at alkaline pH (~5.5–6.8), enabling targeted delivery in the small intestine.
  • Stable and Durable Provides a strong and consistent enteric film even in challenging processing conditions.
  • Solvent-Based System Ideal for moisture-sensitive actives and formulations where aqueous coating is unsuitable.
Application in products
Pharmaceutical Tablets
  • Immediate-release tablets
  • Sustained-release tablets
Technical specifications 
  • Appearance: Clear to slightly hazy solution in organic solvents
  • Solubility: Soluble in alcohols or acetone-based systems
  • pH Threshold for Dissolution: 5.5 – 6.8
  • Film Type: Enteric (gastro-resistant)
  • Coating System: Non-aqueous
  • Viscosity: Medium to high (depending on solvent and polymer concentration)
  • Recommended Use Level: 3–8% weight gain depending on formulation
Safety and Toxicology
  • Non-toxic: Contains GRAS-status excipients and enteric polymers
  • Dermatological safety: Non-sensitizing; avoid inhalation of vapors during processing
Storage and Handling
  • Store in a tightly sealed metal or solvent-resistant container
  • Keep in a cool, ventilated area away from ignition sources
  • Mix thoroughly before use to ensure uniformity
Packaging and Retesting
  • 25 kg metal cans or solvent-safe HDPE containers
  • Retest every 18 months to confirm viscosity, film-forming properties, and pH-triggered performance
Frequently Asked Questions

Your questions our answers.

How does Orynocoat work?
Orynocoat forms a protective film over tablets, controlling drug release and enhancing stability.
What are the key benefits of using Orynocoat?
It improves tablet stability, masks taste, ensures controlled release, and enhances patient compliance.
How is Orynocoat used in formulations?
It is applied as a film coating over tablets using a polymer dispersion technique.
What are the safety considerations for using Orynocoat?
It is non-toxic, safe for oral use, and complies with pharmaceutical safety standards.